January 25th 2024
The expanded indication makes dupilumab the only approved treatment for eosinophilic esophagitis (EoE) in this age group.
Turning Food Allergy Triggers Into Therapy: A Managed Care Lens on Immunotherapy and Targeted Biologics
1.5 Credits / Immunology
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Targeted Therapies for the Management of Eosinophilic Esophagitis Across the Life Cycle: The Role of the Pharmacist in Patient Identification and Optimization, featuring a Pat...
1.5 Credits / Immunology
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Managed Care Perspectives on the Burden of Food Allergies and Advances in Treatment
1.5 Credits / Allergy, Immunology
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Success in Eosinophil-Targeted Treatments for EoE Remains Limited
September 2nd 2022The researchers compiled data from studies of lirentelimab, mepolizumab, reslizumab, and benralizumab, highlighting the difficulties in finding an effective approach with eosinophil-targeted treatments for eosinophilic esophagitis (EoE).
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Bradykinin Level Displays Biomarker Benefit in Nasal Polyposis
August 30th 2022With evidence lacking on the role of inflammation in nasal polyposis (NP), this study investigated the role of 2 potential biomarkers in the nasal secretions of patients who have NP concomitant with aspirin-exacerbated respiratory disease.
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Combination Treatment Provides Short-term Endoscopic Relief in CRSwNP Subtype
August 25th 2022This study investigated combination treatment of antibiotics plus corticosteroids among persons with aspirin-exacerbated respiratory disease, a subtype of chronic rhinosinusitis with nasal polyposis (CRSwNP).
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Adherence to INC Treatment for Nasal Polyposis Remains Low
August 18th 2022Despite intranasal corticosteroid (INCs) being a treatment mainstay for chronic rhinosinusitis with nasal polyps, there are ongoing high rates of nonadherence, which can affect treatment efficacy, according to this study’s authors.
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Researchers Advocate for Closer Monitoring of Patients With EoE
August 12th 2022A study of adult patients with eosinophilic esophagitis in remission showed that those who were followed more closely in the maintenance phase of treatment had fewer strictures and had their disease activity found earlier.
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Better Knowledge of EoE Results in Reduced Diagnostic Delay for European Patients
August 8th 2022European patients with eosinophilic esophagitis (EoE) had an improved diagnosis process and a faster diagnosis as new clinical practice guidelines were published over time, according to the results of a recent study.
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Linked Color Imaging May Improve Diagnostic Accuracy for Eosinophilic Esophagitis
July 28th 2022Diagnostic accuracy for eosinophilic esophagitis (EoE) was higher when white light images were used with linked color imaging rather than alone, suggesting that linked color imaging may be used to reduce diagnostic disparities among endoscopists.
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Case Study Details Challenges in Eosinophilic Gastritis Management
July 21st 2022Nonspecific clinical symptoms can make identifying eosinophilic gastritis difficult, but detailed examination, biopsy, and testing can rule out other possible causes of eosinophilic infiltration of the gastric mucosa.
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Calprotectin’s Role as Biomarker in CRSwNP Investigated in Italian Study
July 14th 2022Conflicting prior study results on the effectiveness of calprotectin expression as a protective or pathologic response among persons with chronic rhinosinusitis with nasal polyps (CRSwNP) spurred this new investigation.
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Dupilumab Safe, Effective Among Patients With Comorbid Asthma, CRSwNP
July 11th 2022Although approved for use among patients with severe or refractory asthma, few studies have investigated its effectiveness among patients with comorbid mild to moderate asthma and chronic rhinosinusitis with nasal polyps (CRSwNP).
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Certain Factors May Reduce ESS-Induced Smell Improvement in CRSwNP
July 9th 2022Endoscopic sinus surgery was associated with improvement in self-reported olfactory function among patients with chronic rhinosinusitis with nasal polyps (CRSwNP), in which a longer CRSwNP disease course and higher blood eosinophilia were cited as risk factors linked with poor sense of smell recovery.
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Dupilumab Demonstrates Safety, Efficacy Across Several Type 2 Inflammatory Diseases
July 2nd 2022Research presented at the European Academy of Allergy and Clinical Immunology Annual Congress show the safety and efficacy of dupilumab across several progressive diseases with underlying type 2 inflammation, including eosinophilic esophagitis (EoE), severe asthma, and severe chronic rhinosinusitis with nasal polyps.
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Self-administration of Biologics Well Tolerated, Effective for Asthma and CRS With Nasal Polyps
June 22nd 2022The adequate safety and improved symptom burden observed with self-administration of biologic therapies at home for the management of severe asthma and chronic rhinosinusitis with nasal polyps suggests potential in shifting care away from the more costlier in-patient setting.
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Nasal Polyps in CRS Found to Influence Risk of Past, Current Proton Pump Inhibitor Use
June 16th 2022Incidence of chronic rhinosinusitis (CRS) was associated with a higher rate of current and past proton pump inhibitor (PPI) use, in which elevated risk of PPI use and prescription duration were only found in those with CRS who did not have nasal polyps.
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Symptom Burden, QOL in CRSwNP Significantly Improved With Novel Fluticasone Delivery System
June 14th 2022Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) who are surgery-naive or whose symptoms recur after endoscopic sinus surgery exhibited similarly significant benefits in quality of life (QOL) and symptom burden when given an exhalation system with fluticasone.
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Dupilumab Efficacy in Asthma, AD, EoE, and CRSwNP Not Affected By Eosinophil Count
June 8th 2022Dupilumab-induced increases in mean eosinophil counts were shown to wane over time in patients with asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and atopic dermatitis (AD), with incidence of eosinophilia not shown to reduce efficacy of the biologic.
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Study Identifies Predictors of Eosinophilic Disease in CRS With Nasal Polyps
June 4th 2022Asthma history and olfactory, rhinorrhea, and nasal polyp endoscopy scores were identified as independent predictors of eosinophilic disease in Chinese patients with chronic rhinosinusitis with nasal polyps.
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Long-term Use of Budesonide Nasal Irrigation Effective for Comorbid CRS With Nasal Polyps, Asthma
June 3rd 2022Patients with comorbid chronic rhinosinusitis (CRS) with nasal polyps and asthma reported significant reductions in endoscopic sinus score and severity, as well as decreased dosage of oral steroids and antibiotics after long-term use of budesonide nasal irrigation.
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