Inflammation

Headaches, injection site reactions, and pharyngitis were the most common adverse events associated with the biologic therapies dupilumab, omalizumab, mepolizumab, and reslizumab in the treatment of chronic rhinosinusitis (CRS) with nasal polyps.

It is already known that patients with eosinophilic esophagitis have higher levels of immunoglobulin G4, and this study examined the relationship to specific foods and aeroallergens.

Although allergic and atopic disease is well studied and researched overall, the researchers said there is a critical lack of knowledge about these conditions, including eosinophilic esophagitis, asthma, and atopic dermatitis, in diverse racial and ethnic groups.

Risk factors as predictors of asthma prevalence among a cohort of patients living with chronic rhinosinusitis (CRS), as they related to age, were evaluated by clinical investigators from the College of Medicine at Korea University.

Using systemic corticosteroids (SCS) to treat chronic rhinosinusitis with nasal polyps (CRSwNP) has been linked to adverse outcomes among patients, prompting these study investigators to compare their health care resource utilization with that of patients who have CRSwNP but don’t use SCS.

A recent study attempted to determine the prevalence of eosinophilic esophagitis (EoE) in a group of patients allergic to milk or egg and undergoing oral immunotherapy (OIT) to those foods, as well as describe its management and treatment pathway.

The researchers compiled data from studies of lirentelimab, mepolizumab, reslizumab, and benralizumab, highlighting the difficulties in finding an effective approach with eosinophil-targeted treatments for eosinophilic esophagitis (EoE).

With evidence lacking on the role of inflammation in nasal polyposis (NP), this study investigated the role of 2 potential biomarkers in the nasal secretions of patients who have NP concomitant with aspirin-exacerbated respiratory disease.

In this study, researchers reaffirmed the safety and efficacy of using budesonide to treat eosinophilic esophagitis (EoE).

This study investigated combination treatment of antibiotics plus corticosteroids among persons with aspirin-exacerbated respiratory disease, a subtype of chronic rhinosinusitis with nasal polyposis (CRSwNP).

Despite intranasal corticosteroid (INCs) being a treatment mainstay for chronic rhinosinusitis with nasal polyps, there are ongoing high rates of nonadherence, which can affect treatment efficacy, according to this study’s authors.

A study of adult patients with eosinophilic esophagitis in remission showed that those who were followed more closely in the maintenance phase of treatment had fewer strictures and had their disease activity found earlier.

European patients with eosinophilic esophagitis (EoE) had an improved diagnosis process and a faster diagnosis as new clinical practice guidelines were published over time, according to the results of a recent study.

This study investigated the potential for postoperative recurrence of chronic rhinosinusitis with nasal polyps (CRSwNP) as measured against B7-H4 expression.

Cow's milk is the most common food trigger for eosinophilic esophagitis (EoE), a chronic inflammatory disease caused by type 2 inflammation.

This new study evaluated outcomes following add-on dupilumab to treat severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP).

The increase in esophageal food impaction can be traced to an increasing incidence and prevalence of eosinophilic esophagitis (EoE), researchers said.

There was also an association between outpatient visit burden and comorbidities and the number of inflammatory upper airway diseases.

Diagnostic accuracy for eosinophilic esophagitis (EoE) was higher when white light images were used with linked color imaging rather than alone, suggesting that linked color imaging may be used to reduce diagnostic disparities among endoscopists.

Nonspecific clinical symptoms can make identifying eosinophilic gastritis difficult, but detailed examination, biopsy, and testing can rule out other possible causes of eosinophilic infiltration of the gastric mucosa.

This new study investigated the ability of a multiparametric model to calculate risk of eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) by comparing its clinical characteristics with noneosinophilic CRSwNP.

A late-stage trial of dupilumab in young children showed the biologic induced remission in eosinophilic esophagitis (EoE).

Conflicting prior study results on the effectiveness of calprotectin expression as a protective or pathologic response among persons with chronic rhinosinusitis with nasal polyps (CRSwNP) spurred this new investigation.

Although approved for use among patients with severe or refractory asthma, few studies have investigated its effectiveness among patients with comorbid mild to moderate asthma and chronic rhinosinusitis with nasal polyps (CRSwNP).

Endoscopic sinus surgery was associated with improvement in self-reported olfactory function among patients with chronic rhinosinusitis with nasal polyps (CRSwNP), in which a longer CRSwNP disease course and higher blood eosinophilia were cited as risk factors linked with poor sense of smell recovery.