January 25th 2024
The expanded indication makes dupilumab the only approved treatment for eosinophilic esophagitis (EoE) in this age group.
Turning Food Allergy Triggers Into Therapy: A Managed Care Lens on Immunotherapy and Targeted Biologics
1.5 Credits / Immunology
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Targeted Therapies for the Management of Eosinophilic Esophagitis Across the Life Cycle: The Role of the Pharmacist in Patient Identification and Optimization, featuring a Pat...
1.5 Credits / Immunology
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Managed Care Perspectives on the Burden of Food Allergies and Advances in Treatment
1.5 Credits / Allergy, Immunology
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Dupilumab Reduces OCS Dosage, Improves Lung Function for Asthma, CRSwNP
May 22nd 2022Dupilumab was associated with reductions in exacerbations and oral corticosteroids (OCS) dosage, as well as improved lung function, in patients with OCS-dependent asthma with and without comorbid chronic rhinosinusitis with nasal polyps.
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Chitosan-Based Gel Found to Lower Risk of Wound Infection, Synechia After Nasal Polyps Surgery
May 20th 2022Use of a chitosan-based gel dressing after endoscopic sinus surgery for nasal polyps was found to reduce risk of wound infection and synechia in patients, although no difference was observed regarding granulations.
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Improved Sense of Smell Achieved With Biologics for CRS With Nasal Polyps, Asthma
May 12th 2022Patients with comorbid chronic rhinosinusitis (CRS) with nasal polyps and severe asthma reported significant improvement in their sense of smell when treated with the biologics omalizumab, mepolizumab, reslizumab, or benralizumab, with no significant differences observed between the treatment groups.
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EoE Research Examines Long-term Efficacy of PPIs in Responders
May 9th 2022A recent study sought to address what is known about proton pump inhibitors (PPIs) as a therapy for eosinophilic esophagitis and long-term outcomes in patients who respond to them as a way to guide treatment decisions.
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Machine Learning Identifies Predictors of Revision Endoscopic Sinus Surgery
May 5th 2022A machine learning approach identified age and several comorbidities, such as nasal polyps and asthma, as being associated with revision endoscopic sinus surgery among patients with chronic rhinosinusitis.
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Clinical Improvement of AERD Achieved With Dupilumab Use for Asthma, CRS With Nasal Polyps
May 3rd 2022Patients with aspirin-exacerbated respiratory disease (AERD) who initiated treatment with dupilumab as an add-on asthma or chronic rhinosinusitis with nasal polyps therapy reported rapid clinical improvement that was sustained after 3 months.
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HPV Infection May Increase Risk of Developing CRS With Nasal Polyps
April 30th 2022Presence of human papillomavirus (HPV) was significantly associated with incidence of chronic rhinosinusitis with nasal polyps (CRSwNP), although no differences in disease severity were observed among HPV-positive and HPV-negative patients with CRSwNP.
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Real-world Patients Show Significant Improvement With Dupilumab for CRS With Nasal Polyps
April 28th 2022Use of dupilumab was associated with significant improvement in clinical symptoms of chronic rhinosinusitis (CRS) with nasal polyps among real-world patients in Canada, with benefits shown to be similar to that observed in randomized clinical trials.
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Surveyed Patients Identify Unmet Needs in CRS With Nasal Polyps
April 23rd 2022Patients with chronic rhinosinusitis (CRS) with nasal polyps identified several unmet needs regarding their condition, particularly a lack of public and physician awareness on disease burden and poor sleep quality.
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In Adults With EoE, Dilation May Mask Underlying Inflammation
April 15th 2022The study was conducted because information on the relationship between eosinophilic esophagitis (EOE) symptoms and biologic findings are limited, so researchers looked at the long-term effects of esophageal dilation, including patient-reported outcome (PRO) measures.
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CRS With Nasal Polyps Linked With Reduced Health-Related QOL Across Patient Subgroups
April 13th 2022Reduced health-related quality of life was identified in patients with chronic rhinosinusitis with nasal polyps compared with the general population—regardless of previous sinus surgery or presence of comorbidities.
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Biomarker Identifies CRSwNP Endotypes, Risk of Postoperative Nasal Polyp Recurrence
April 9th 2022Circulating B cell–activating factor was shown to be a potential biomarker in identifying blood eosinophil counts and risk of postoperative nasal polyp recurrence among patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
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Older EoE Patients More Likely to Respond to Topical Corticosteroids, Study Finds
April 8th 2022Recent clinical trials have excluded older patients with eosinophilic esophagitis (EoE) from participating; however, patients aged 65 years and older are more likely to respond to topical corticosteroids than their younger counterparts.
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Consider Screening Patients With Food Allergy for EoE, Pilot Study Says
April 6th 2022A recent study found a correlation in patients with an IgE-mediated food allergy (IgE-FA) reporting symptoms of eosinophilic esophagitis (EoE), leading researchers to conclude screening for EoE may be beneficial.
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More Symptom-Free Days Reported With Dupilumab Use in CRS With Nasal Polyps
April 2nd 2022A significantly greater proportion of patients with chronic rhinosinusitis with nasal polyps reported symptom-free days for at least 1 symptom when treated with dupilumab vs placebo in the 28 days preceding 24-week and 52-week analysis intervals.
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Age Linked With Treatment Outcomes in Noneosinophilic CRS With Nasal Polyps
March 31st 2022Younger and older patients with noneosinophilic chronic rhinosinusitis (CRS) with nasal polyps showed significant differences in preoperative blood eosinophil levels and postoperative modified Lund-Kennedy scores.
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Meta-Analysis Finds Dupilumab Most Effective Biologic for CRS With Nasal Polyps
March 25th 2022A comparison of type 2 biologics indicated for the treatment of chronic rhinosinusitis with nasal polyps identified dupilumab as the most effective drug in decreasing nasal polyp score and nasal congestion severity, whereas benralizumab was least effective.
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Adjuvant Oral, Nasal Steroids Found to Improve Olfactory Function in CRS With Nasal Polyps
March 23rd 2022Patients with chronic rhinosinusitis (CRS) with nasal polyps exhibited significant improvement in olfactory function when treated with a combination of oral and nasal steroids vs nasal steroids alone.
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